Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 1.00 |
| ▸ | ABL2 | P42684 | 2/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.86 |
| ▸ | GAK | O14976 | 1/20 | 0.86 |
| ▸ | MLNR | O43193 | 1/20 | 0.86 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.86 |
| ▸ | JAK2 | O60674 | 1/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.86 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.86 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.86 |
| ▸ | EGFR | P00533 | 1/20 | 0.86 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.86 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.86 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.86 |
| ▸ | LCK | P06239 | 1/20 | 0.86 |
| ▸ | FYN | P06241 | 1/20 | 0.86 |
| ▸ | PGR | P06401 | 1/20 | 0.86 |
| ▸ | CSF1R | P07333 | 1/20 | 0.86 |
| ▸ | YES1 | P07947 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30464941 | 1.00 | ABL1 (1.00) | ABL1ABL2CYP3A4KCNH2GAK | |
| SCHEMBL588523 | 1.00 | ABL1 (1.00) | ABL1ABL2CYP3A4KCNH2GAK | |
| Hydrochloric Acid SCHEMBL25235834 | 0.99 | ABL1 (0.99) | ABL1ABL2CYP3A4KCNH2GAK | |
| Hydrochloric Acid SCHEMBL30459675 | 0.99 | ABL1 (0.99) | ABL1ABL2CYP3A4KCNH2GAK | |
| SCHEMBL15144985 | 0.94 | ABL1 (0.89) | ABL1ABL2CYP3A4KCNH2GAK | |
| SCHEMBL20143350 | 0.93 | ABL1 (0.91) | ABL1ABL2CYP3A4KCNH2GAK | |
| SCHEMBL15294699 | 0.92 | ABL1 (1.00) | ABL1ABL2CYP3A4KCNH2GAK | |
| Ponatinib SCHEMBL29353054 | 0.92 | ABL1 (1.00) | ABL1ABL2CYP3A4KCNH2GAK | |
| SCHEMBL24685833 | 0.92 | ABL1 (0.90) | ABL1ABL2CYP3A4KCNH2GAK | |
| Ponatinib SCHEMBL589260 | 0.92 | ABL1 (1.00) | ABL1ABL2CYP3A4KCNH2GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120202200-A | Oxo-isoindolinyl substituted tetrahydropyrimidinedione-based compounds and applications thereof | 标新生物医药科技(上海)有限公司 | 2025-06-24 | — | — | CN | disclosed |
| EP-4232023-A1 | COMPOUNDS FOR TARGETED PROTEIN DEGRADATION OF KINASES | Dana-Farber Cancer Institute, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022093742-A1 | COMPOUNDS FOR TARGETED PROTEIN DEGRADATION OF KINASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-05-05 | — | — | WO | disclosed |
| CN-110357889-B | Protein degradation targeting compound, anti-tumor application thereof, intermediate thereof and application of intermediate | 上海科技大学 | 2022-03-15 | — | — | CN | disclosed |