Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | CA1 | P00915 | 5/20 | 0.60 |
| ▸ | CA2 | P00918 | 5/20 | 0.60 |
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29664409 | 0.82 | CCNT1 (0.53) | KMT2AMEN1RXFP1CA1CA2 | |
| SCHEMBL29618343 | 0.82 | CA1 (0.57) | KMT2AMEN1RXFP1CA1CA2 | |
| SCHEMBL29618348 | 0.81 | NPC1 (0.57) | KMT2AMEN1RXFP1NPC1RAB9A | |
| SCHEMBL29618356 | 0.79 | CA1 (0.57) | KMT2AMEN1RXFP1CA1CA2 | |
| SCHEMBL11961607 | 0.79 | NPC1 (0.71) | KMT2AMEN1RXFP1NPC1RAB9A | |
| SCHEMBL13764406 | 0.78 | MEN1 (0.76) | KMT2AMEN1NPC1RAB9ACA1 | |
| SCHEMBL14372397 | 0.78 | MEN1 (0.67) | KMT2AMEN1NPC1RAB9ACA1 | |
| SCHEMBL14372330 | 0.78 | MEN1 (0.76) | KMT2AMEN1NPC1RAB9ACA1 | |
| SCHEMBL14372369 | 0.78 | CA1 (0.76) | KMT2AMEN1CA1CA2CA12 | |
| SCHEMBL14372342 | 0.78 | CA1 (0.71) | KMT2AMEN1NPC1RAB9ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022121805-A1 | FUSED RING COMPOUND AS NAV1.8 INHIBITOR AND USE THEREOF | 成都康弘药业集团股份有限公司 | 2022-06-16 | — | — | WO | disclosed |
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |