Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 6/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295593 | 0.88 | SMN1; SMN2 (0.41) | S1PR2S1PR1S1PR3LPAR2SMN1; SMN2 | |
| SCHEMBL296488 | 0.83 | SMN1; SMN2 (0.39) | S1PR1S1PR3SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL295021 | 0.80 | S1PR1 (0.48) | S1PR2S1PR1S1PR3LPAR2SMN1; SMN2 | |
| SCHEMBL295020 | 0.80 | S1PR1 (0.48) | S1PR2S1PR1S1PR3LPAR2SMN1; SMN2 | |
| SCHEMBL296595 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1THRBKMT2AKDM4E | |
| SCHEMBL295919 | 0.79 | S1PR1 (0.41) | S1PR2S1PR1S1PR3LPAR2SMN1; SMN2 | |
| SCHEMBL296830 | 0.77 | S1PR1 (0.54) | S1PR1S1PR3SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL295947 | 0.77 | S1PR2 (0.36) | S1PR2S1PR1S1PR3LPAR2SMN1; SMN2 | |
| SCHEMBL12721394 | 0.76 | S1PR1 (0.56) | S1PR1S1PR3SMN1; SMN2KMT2AUSP2 | |
| SCHEMBL1624956 | 0.76 | S1PR1 (0.56) | S1PR1S1PR3SMN1; SMN2KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636171-B1 | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| US-7696184-B2 | Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator | NOVARTIS AG (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20070010494-A1 | Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator | NOVARTIS AG (CH) | 2007-01-11 | — | — | US | disclosed |
| EP-1636171-A2 | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATOR | Novartis AG (CH) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110979-A2 | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATOR | NOVARTIS AG (CH) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010494-A1 | Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator | S1PR1, S1PR3, S1PR2 | S1PR2 3/4885S1PR1 1/4885S1PR3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.