Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4662240 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL764578 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL6525814 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL19578680 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL56746 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL6525816 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL8303249 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL22242735 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| SCHEMBL21238714 | 1.00 | BTK (0.51) | BTKGAAEPHX1NFKB1NFKB2 | |
| Ammonia Solution, Strong SCHEMBL6519837 | 0.98 | BTK (0.50) | BTKGAAEPHX1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022093820-A1 | SUBSTITUTED MORPHOLINE COMPOUNDS | GENENTECH, INC. (US) | 2022-05-05 | — | — | WO | disclosed |