Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.49 |
| ▸ | HTR2C | P28335 | 17/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24398571 | 1.00 | HTR2A (0.49) | HTR2AHTR2CBRD4BRD2BRD3 | |
| SCHEMBL29619062 | 0.90 | HTR2A (0.49) | HTR2AHTR2C | |
| SCHEMBL24398369 | 0.90 | HTR2A (0.49) | HTR2AHTR2C | |
| SCHEMBL24398418 | 0.90 | HTR2A (0.49) | HTR2AHTR2C | |
| SCHEMBL29619051 | 0.88 | HTR2A (0.51) | HTR2AHTR2C | |
| SCHEMBL29619156 | 0.87 | HTR2A (0.46) | HTR2AHTR2CBRD4BRD2BRD3 | |
| SCHEMBL29619101 | 0.86 | HTR2A (0.49) | HTR2AHTR2CBRD4BRD2BRD3 | |
| SCHEMBL29619125 | 0.85 | HTR2A (0.44) | HTR2AHTR2CBRD4BRD2BRD3 | |
| SCHEMBL29619153 | 0.81 | HTR2A (0.51) | HTR2AHTR2CBRD4BRD2BRD3 | |
| SCHEMBL29619056 | 0.81 | HTR2A (0.53) | HTR2AHTR2CBRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |