SCHEMBL29619233

SCHEMBL29619233

CC(=O)Nc1cc2c(=O)n(CC3(O)CCN(C(=O)CC(C)c4ccccc4)CC3)cnn2c1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
USP7 Q93009 14/20 0.78
USP19 O94966 6/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17868433 1.00 USP7 (0.78) USP7USP19
SCHEMBL17868434 1.00 USP7 (0.78) USP7USP19
SCHEMBL17868543 0.92 USP7 (0.75) USP7USP19
SCHEMBL17868542 0.92 USP7 (0.75) USP7USP19
SCHEMBL17868484 0.88 USP7 (1.00) USP7USP19
SCHEMBL17868508 0.87 USP7 (1.00) USP7USP19
SCHEMBL17868408 0.83 USP7 (0.76) USP7USP19
SCHEMBL17868398 0.83 USP7 (0.76) USP7USP19
SCHEMBL20864562 0.81 USP7 (0.80) USP7USP19
SCHEMBL17966254 0.81 USP7 (0.80) USP7USP19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220125760-A1 USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) UNIVERSITÉ PAUL SABATIER TOULOUSE III (FR) 2022-04-28 US disclosed