Sugi Predict

Sugi Predict / Compounds / SCHEMBL29619702

SCHEMBL29619702

SCHEMBL29619702

COC(=O)C1CC(Oc2ccc(F)cc2C2CCN([C@@H]3COC4(C3)CN(c3nnco3)C4)CC2)C1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CHRM4 P08173 8/20 0.56
▸ CHRM1 P11229 8/20 0.56
▸ CHRM2 P08172 3/20 0.47
▸ CHRM5 P08912 1/20 0.47
▸ DRD2 P14416 3/20 0.33
▸ ADRA1D P25100 3/20 0.33
▸ ADRA1A P35348 3/20 0.33
▸ ADRA1B P35368 3/20 0.33
▸ DPP4 P27487 1/20 0.32
▸ DPP8 Q6V1X1 1/20 0.32
▸ DPP9 Q86TI2 1/20 0.32
▸ DPP7 Q9UHL4 1/20 0.32
▸ MAPT P10636 1/20 0.30
▸ GPR6 P46095 1/20 0.30
▸ MET P08581 1/20 0.30
▸ KDR P35968 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23213603 0.93 CHRM4 (0.54) CHRM4CHRM1CHRM2CHRM5
SCHEMBL23213606 0.93 CHRM4 (0.54) CHRM4CHRM1CHRM2CHRM5
SCHEMBL23213356 0.89 CHRM4 (0.55) CHRM4CHRM1CHRM2CHRM5DRD2
SCHEMBL23213357 0.89 CHRM4 (0.55) CHRM4CHRM1CHRM2CHRM5DRD2
SCHEMBL23329061 0.88 CHRM4 (0.51) CHRM4CHRM1CHRM2CHRM5
SCHEMBL23329060 0.88 CHRM4 (0.51) CHRM4CHRM1CHRM2CHRM5
SCHEMBL29619506 0.88 CHRM4 (0.51) CHRM4CHRM1CHRM2CHRM5
SCHEMBL23212981 0.88 CHRM4 (0.51) CHRM4CHRM1CHRM2CHRM5
SCHEMBL23212985 0.88 CHRM4 (0.51) CHRM4CHRM1CHRM2CHRM5
SCHEMBL23230098 0.88 CHRM4 (0.50) CHRM4CHRM1CHRM2CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240140959-A1 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS NOVARTIS AG (CH) 2024-05-02 — — US disclosed
US-11820778-B2 2-azaspiro[3.4]octane derivatives as M4 agonists NOVARTIS AG (CH) 2023-11-21 — — US disclosed
US-20220411435-A1 2-AZASPIRO[3,4]OCTANE DERIVATIVES AS M4 AGONISTS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2022-12-29 — — US disclosed
US-11485742-B2 2-azaspiro[3.4]octane derivatives as M4 agonists NOVARTIS AG (CH) 2022-11-01 — — US disclosed
EP-4041737-A1 5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS Novartis AG (CH) 2022-08-17 — — EP disclosed
CN-114555606-A 5-oxa-2-azaspiro [3.4] octane derivatives as M4 agonists 诺华股份有限公司 2022-05-27 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11485742-B2 2-azaspiro[3.4]octane derivatives as M4 agonists CHRM2, CHRM1, CHRM3 CHRM4 4/4885CHRM1 2/4885CHRM2 1/4885
US-20240140959-A1 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS CHRM2, CHRM1, CHRM3 CHRM4 4/4885CHRM1 2/4885CHRM2 1/4885
US-20220411435-A1 2-AZASPIRO[3,4]OCTANE DERIVATIVES AS M4 AGONISTS CHRM2, CHRM1, CHRM3 CHRM4 4/4885CHRM1 2/4885CHRM2 1/4885
US-11820778-B2 2-azaspiro[3.4]octane derivatives as M4 agonists CHRM2, CHRM1, CHRM3 CHRM4 4/4885CHRM1 2/4885CHRM2 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.