SCHEMBL29620199

SCHEMBL29620199

Cn1c(C(=O)Nc2cccc(Br)c2Cl)nc2c1CCNC2

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 20/20 0.81
CD274 Q9NZQ7 20/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21564993 1.00 PDCD1 (0.81) PDCD1CD274
SCHEMBL20294094 0.90 PDCD1 (1.00) PDCD1CD274
Hydrochloric Acid SCHEMBL23363718 0.89 PDCD1 (0.98) PDCD1CD274
SCHEMBL23633083 0.89 PDCD1 (0.72) PDCD1CD274
SCHEMBL21564991 0.87 PDCD1 (0.77) PDCD1CD274
SCHEMBL21565783 0.86 PDCD1 (0.92) PDCD1CD274
SCHEMBL20294132 0.85 PDCD1 (1.00) PDCD1CD274
SCHEMBL22660179 0.85 PDCD1 (0.79) PDCD1CD274
SCHEMBL20294313 0.85 PDCD1 (0.74) PDCD1CD274
SCHEMBL29447335 0.85 PDCD1 (0.79) PDCD1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025029075-A1 NOVEL BIPHENYL DERIVATIVE AS PD-L1 INHIBITOR (주)아이랩 2025-02-06 WO disclosed
WO-2024018403-A1 SUBSTITUTED IMIDAZOAMIDE COMPOUNDS, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-01-25 WO disclosed
CN-112812113-B Immunomodulatory compounds, compositions and uses thereof 杭州和正医药有限公司 2022-09-20 CN disclosed
WO-2022161421-A1 BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF 深圳微芯生物科技股份有限公司 2022-08-04 WO disclosed
CN-114650993-A PD-1/PD-L1 inhibitor and preparation method and application thereof 上海华汇拓医药科技有限公司 2022-06-21 CN disclosed
WO-2022089511-A1 BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 深圳微芯生物科技股份有限公司 2022-05-05 WO disclosed