⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8677927 | 0.60 | — | — | |
| SCHEMBL8404594 | 0.57 | — | — | |
| SCHEMBL735080 | 0.54 | — | — | |
| SCHEMBL6850987 | 0.54 | GSK3A (0.44) | — | |
| SCHEMBL10483659 | 0.53 | — | — | |
| SCHEMBL7223719 | 0.53 | — | — | |
| SCHEMBL14965051 | 0.53 | — | — | |
| SCHEMBL11414636 | 0.52 | GSK3A (0.35) | — | |
| SCHEMBL619767 | 0.51 | — | — | |
| SCHEMBL133474 | 0.49 | GSK3A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778023-B1 | Product comprising rapamycin or particular derivatives and an NMDA or AMPA antagonist for use for the treatment of epilepsy or Huntington's Disease, and the use of rapamycin or particular derivatives for the manufacture of a medicament for the treatment of epilepsy or Huntington's Disease. | WYETH CORP (US) | 2003-03-12 | — | — | EP | claimed |
| EP-0778023-A1 | Neuroprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-11 | — | — | EP | claimed |
| JP-9183727-A | — | — | None | — | — | JP | disclosed |
| EP-1828202-B1 | RAPAMCYIN ANALOGUES AND THE USES THEREOF IN THE TREATMENT OF NEUROLOGICAL, PROLIFERATIVE AND INFLAMMATORY DISORDERS | WYETH LLC (US) | 2012-03-14 | — | — | EP | disclosed |
| CN-1112925-C | Neuroprotective agents | WYETH CORP (US) | 2003-07-02 | — | — | CN | disclosed |
| EP-0778023-B1 | Product comprising rapamycin or particular derivatives and an NMDA or AMPA antagonist for use for the treatment of epilepsy or Huntington's Disease, and the use of rapamycin or particular derivatives for the manufacture of a medicament for the treatment of epilepsy or Huntington's Disease. | WYETH CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| CN-1159915-A | Neuroprotective agents | AMERICAN HOME PROD (US) | 1997-09-24 | — | — | CN | disclosed |
| JP-H09183727-A | PROTECTIVE FOR NERVE | AMERICAN HOME PROD CORP | 1997-07-15 | — | — | JP | disclosed |
| EP-0778023-A1 | Neuroprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0778023-A1 | Neuroprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-11 | — | — | EP | disclosed |