Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.73 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.73 |
| ▸ | STAT3 | P40763 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.64 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.64 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | IL1B | P01584 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.56 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SNCA | P37840 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17859029 | 1.00 | CRBN (0.73) | CRBNDDB1STAT3HDAC1HDAC6 | |
| SCHEMBL23796444 | 0.95 | CRBN (0.70) | CRBNDDB1STAT3HDAC1HDAC6 | |
| Trifluoroacetic Acid SCHEMBL17839625 | 0.94 | CRBN (0.68) | CRBNDDB1STAT3HDAC1HDAC6 | |
| SCHEMBL17859033 | 0.94 | STAT3 (0.71) | CRBNDDB1STAT3HDAC1HDAC6 | |
| SCHEMBL29622126 | 0.94 | STAT3 (0.71) | CRBNDDB1STAT3HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL30893263 | 0.93 | STAT3 (0.70) | CRBNDDB1STAT3HDAC1HDAC6 | |
| SCHEMBL21070244 | 0.93 | STAT3 (0.70) | CRBNDDB1STAT3HDAC1HDAC6 | |
| SCHEMBL17859010 | 0.93 | STAT3 (0.70) | CRBNDDB1STAT3HDAC1HDAC6 | |
| SCHEMBL24142023 | 0.93 | STAT3 (0.70) | CRBNDDB1STAT3HDAC1HDAC6 | |
| SCHEMBL17859058 | 0.93 | STAT3 (0.70) | CRBNDDB1STAT3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |