Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 9/20 | 0.64 |
| ▸ | AURKA | O14965 | 8/20 | 0.64 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | CD38 | P28907 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712006 | 0.81 | RPS6KB1 (0.63) | RPS6KB1AURKAJAK3JAK2JAK1 | |
| SCHEMBL22261183 | 0.80 | JAK3 (0.58) | RPS6KB1AURKAJAK3JAK2JAK1 | |
| SCHEMBL666783 | 0.78 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL30240978 | 0.77 | SYK (0.57) | RPS6KB1AURKAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7119744 | 0.76 | KDR (0.62) | RPS6KB1AURKAJAK3JAK2JAK1 | |
| SCHEMBL26921635 | 0.75 | AURKA (0.55) | RPS6KB1AURKAJAK3JAK2JAK1 | |
| SCHEMBL2476571 | 0.73 | CD38 (0.54) | RPS6KB1AURKAJAK3JAK2JAK1 | |
| SCHEMBL22261088 | 0.71 | JAK3 (0.80) | JAK3JAK2JAK1STAT6 | |
| SCHEMBL29622729 | 0.71 | CYP1A2 (0.58) | RPS6KB1AURKAJAK3ALDH1A1CYP1A2 | |
| SCHEMBL22261275 | 0.71 | JAK3 (0.60) | RPS6KB1AURKAJAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344549-B2 | 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2022-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344549-B2 | 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof | JAK1, JAK3, JAK2 | RPS6KB1 2079/4885AURKA 187/4885JAK3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.