Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.50 |
| ▸ | MERTK | Q12866 | 2/20 | 0.50 |
| ▸ | GALR2 | O43603 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16812342 | 0.80 | JAK3 (0.62) | JAK3JAK1JAK2 | |
| SCHEMBL30455447 | 0.79 | JAK3 (0.83) | JAK3JAK1JAK2 | |
| SCHEMBL22261158 | 0.79 | JAK3 (0.83) | JAK3JAK1JAK2 | |
| SCHEMBL16812340 | 0.77 | JAK2 (0.51) | JAK3JAK1JAK2LRRK2 | |
| SCHEMBL15547156 | 0.77 | JAK3 (0.55) | JAK3JAK1JAK2 | |
| SCHEMBL29622803 | 0.76 | JAK3 (0.51) | JAK3JAK1JAK2LRRK2PLK4 | |
| SCHEMBL29622793 | 0.76 | AURKB (0.48) | JAK3JAK1JAK2LRRK2 | |
| SCHEMBL15546989 | 0.76 | JAK3 (0.55) | JAK3JAK1JAK2TTK | |
| SCHEMBL15534846 | 0.76 | JAK1 (0.52) | JAK3JAK1JAK2LRRK2 | |
| SCHEMBL1662547 | 0.75 | IGF1R (0.53) | JAK3IGF1RDDR2AXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344549-B2 | 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2022-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344549-B2 | 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof | JAK1, JAK3, JAK2 | JAK3 2/4885AURKA 187/4885IGF1R 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.