Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.51 |
| ▸ | JAK2 | O60674 | 11/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | TYK2 | P29597 | 10/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23088769 | 0.83 | JAK1 (0.52) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL29622910 | 0.82 | JAK3 (0.50) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL23088777 | 0.82 | JAK3 (0.54) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL23088766 | 0.82 | JAK3 (0.49) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL29622803 | 0.81 | JAK3 (0.51) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL15557108 | 0.81 | JAK1 (0.47) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL29622869 | 0.80 | JAK3 (0.52) | JAK1JAK2JAK3TYK2AURKB | |
| SCHEMBL29622819 | 0.80 | JAK3 (0.52) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL23088802 | 0.78 | JAK1 (0.61) | JAK1JAK2JAK3TYK2STAT3 | |
| SCHEMBL22261167 | 0.78 | JAK3 (0.81) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344549-B2 | 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2022-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344549-B2 | 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof | JAK1, JAK3, JAK2 | JAK1 1/4885JAK2 3/4885JAK3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.