Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | USP2 | O75604 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | ALPG | P10696 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297577 | 0.89 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL27796460 | 0.85 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL300827 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL301309 | 0.83 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL296211 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL292729 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL291560 | 0.82 | KDM4E (0.81) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL300846 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL19207479 | 0.82 | KDM4E (0.74) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL300886 | 0.82 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-110721186-A | Treatment of prostate cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-24 | — | — | CN | disclosed |
| CN-107157990-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-102821767-A | IDENTIFICATION OF LKB1 MUTATION AS A PREDICTIVE BIOMARKER FOR SENSITIVITY TO TOR KINASE INHIBITORS | SIGNAL PHARM LLC | 2012-12-12 | — | — | CN | disclosed |