Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.61 |
| ▸ | RAF1 | P04049 | 8/20 | 0.57 |
| ▸ | FLT3 | P36888 | 6/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350893 | 1.00 | BRAF (0.61) | BRAFRAF1FLT3MAPK14MEN1 | |
| SCHEMBL29623754 | 0.88 | FLT3 (0.61) | RAF1FLT3MAPK14MEN1NPC1 | |
| SCHEMBL19350750 | 0.88 | FLT3 (0.61) | RAF1FLT3MAPK14MEN1NPC1 | |
| SCHEMBL19350833 | 0.88 | RAF1 (0.64) | BRAFRAF1FLT3MAPK14MEN1 | |
| SCHEMBL29623204 | 0.88 | RAF1 (0.64) | BRAFRAF1FLT3MAPK14MEN1 | |
| SCHEMBL29623298 | 0.88 | RAF1 (0.64) | BRAFRAF1FLT3MAPK14MEN1 | |
| SCHEMBL19350737 | 0.88 | RAF1 (0.64) | BRAFRAF1FLT3MAPK14MEN1 | |
| SCHEMBL19350883 | 0.85 | FLT3 (0.56) | RAF1FLT3MAPK14MEN1NPC1 | |
| SCHEMBL19350796 | 0.85 | MAPK14 (0.67) | RAF1FLT3MAPK14MEN1NPC1 | |
| SCHEMBL29623488 | 0.85 | MAPK14 (0.67) | RAF1FLT3MAPK14MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | claimed |
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |