Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208102 | 1.00 | EGFR (0.75) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL185179 | 1.00 | EGFR (0.75) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL3584884 | 0.96 | EGFR (0.76) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL3584888 | 0.96 | EGFR (0.76) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1190971 | 0.94 | EGFR (0.74) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1190970 | 0.94 | EGFR (0.74) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1190009 | 0.92 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1190010 | 0.92 | EGFR (0.72) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL3577825 | 0.92 | EGFR (0.73) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL3577826 | 0.92 | EGFR (0.73) | EGFRERBB2JAK3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436446-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2023-06-07 | — | — | EP | disclosed |
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-110713489-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-110183440-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-04-22 | — | — | CN | disclosed |