Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.78 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.69 |
| ▸ | JAK3 | P52333 | 1/20 | 0.69 |
| ▸ | CIT | O14578 | 1/20 | 0.67 |
| ▸ | GAK | O14976 | 1/20 | 0.67 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | ABL1 | P00519 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | LYN | P07948 | 1/20 | 0.67 |
| ▸ | RET | P07949 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | MET | P08581 | 1/20 | 0.67 |
| ▸ | HCK | P08631 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185032 | 1.00 | EGFR (0.78) | EGFRERBB2ERBB4JAK3CIT | |
| SCHEMBL231418 | 1.00 | EGFR (0.78) | EGFRERBB2ERBB4JAK3CIT | |
| SCHEMBL3578016 | 0.94 | EGFR (0.72) | EGFRERBB2ERBB4JAK3CIT | |
| SCHEMBL3578019 | 0.94 | EGFR (0.72) | EGFRERBB2ERBB4JAK3CIT | |
| SCHEMBL1190010 | 0.94 | EGFR (0.72) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL1190009 | 0.94 | EGFR (0.72) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL185736 | 0.93 | EGFR (0.82) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL231276 | 0.93 | EGFR (0.82) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL29623503 | 0.93 | EGFR (0.82) | EGFRERBB2ERBB4CITGAK | |
| SCHEMBL1191175 | 0.93 | EGFR (0.74) | EGFRERBB2ERBB4CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4223294-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MEDIATED DISEASES | Vertex Pharmaceuticals Incorporated (US) | 2023-08-09 | — | — | EP | disclosed |
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-110713489-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-110183440-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-04-22 | — | — | CN | disclosed |