Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.73 |
| ▸ | CIT | O14578 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.65 |
| ▸ | STK17B | O94768 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186516 | 1.00 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL206653 | 1.00 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL29623540 | 1.00 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL6990366 | 1.00 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL1383708 | 1.00 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL6987775 | 0.96 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL7219510 | 0.96 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL6987341 | 0.96 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL6994030 | 0.96 | EGFR (0.73) | EGFRCITGAKEPHB6ABCC4 | |
| SCHEMBL6990969 | 0.96 | EGFR (0.70) | EGFRCITGAKEPHB6ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110713489-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-110183440-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-04-22 | — | — | CN | disclosed |