Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.83 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.83 |
| ▸ | GAK | O14976 | 2/20 | 0.83 |
| ▸ | ABL1 | P00519 | 2/20 | 0.83 |
| ▸ | LCK | P06239 | 2/20 | 0.83 |
| ▸ | MET | P08581 | 2/20 | 0.83 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.83 |
| ▸ | BLK | P51451 | 2/20 | 0.83 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.83 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.83 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.83 |
| ▸ | EPHA6 | Q9UF33 | 2/20 | 0.83 |
| ▸ | CIT | O14578 | 1/20 | 0.83 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.83 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.83 |
| ▸ | STK10 | O94804 | 1/20 | 0.83 |
| ▸ | LYN | P07948 | 1/20 | 0.83 |
| ▸ | RET | P07949 | 1/20 | 0.83 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185664 | 1.00 | EGFR (0.83) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL232499 | 1.00 | EGFR (0.83) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1191741 | 0.99 | EGFR (0.83) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1191743 | 0.99 | EGFR (0.83) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL29623517 | 0.94 | EGFR (0.85) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1191232 | 0.94 | EGFR (0.92) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL232078 | 0.94 | EGFR (0.85) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL232077 | 0.94 | EGFR (0.85) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1190665 | 0.93 | EGFR (0.73) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1190662 | 0.93 | EGFR (0.73) | EGFRERBB2ERBB4GAKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-110713489-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-110183440-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-04-22 | — | — | CN | disclosed |