Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 10/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | MC3R | P41968 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL232373 | 1.00 | EGFR (0.56) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL232374 | 1.00 | EGFR (0.56) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL185491 | 1.00 | EGFR (0.56) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1190783 | 0.99 | EGFR (0.56) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1190781 | 0.99 | EGFR (0.56) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1190779 | 0.99 | EGFR (0.56) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL30510440 | 0.93 | EGFR (0.51) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL252516 | 0.90 | EGFR (0.58) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1191562 | 0.90 | EGFR (0.58) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL252515 | 0.90 | EGFR (0.58) | EGFRERBB2ERBB4JAK3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-110713489-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-110183440-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-04-22 | — | — | CN | disclosed |