Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231729 | 1.00 | EGFR (0.70) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL13606740 | 1.00 | EGFR (0.70) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL185864 | 1.00 | EGFR (0.70) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL5223991 | 0.96 | EGFR (0.72) | EGFRERBB2 | |
| SCHEMBL7219629 | 0.96 | EGFR (0.72) | EGFRERBB2 | |
| SCHEMBL1446628 | 0.95 | EGFR (0.65) | EGFRERBB2KDREPHB4 | |
| SCHEMBL4523013 | 0.93 | EGFR (0.77) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL4523002 | 0.93 | EGFR (0.77) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL13606791 | 0.93 | EGFR (0.77) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL4524312 | 0.93 | EGFR (0.77) | EGFRERBB2EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-110713489-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-110183440-B | Heteroaryl SYK inhibitors | 勃林格殷格翰国际有限公司 | 2022-04-22 | — | — | CN | disclosed |