Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 13/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 5/20 | 0.52 |
| ▸ | RET | P07949 | 4/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350850 | 1.00 | MAPK14 (0.56) | MAPK14KDRAURKAAURKBFLT3 | |
| SCHEMBL29623488 | 0.90 | MAPK14 (0.67) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL19350796 | 0.90 | MAPK14 (0.67) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL19350883 | 0.89 | FLT3 (0.56) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL29623670 | 0.89 | FLT3 (0.61) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL29623236 | 0.89 | FLT3 (0.56) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL19350706 | 0.89 | FLT3 (0.61) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL19350848 | 0.87 | RAF1 (0.53) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL29623376 | 0.87 | RAF1 (0.53) | MAPK14KDRFLT3MEN1NPC1 | |
| SCHEMBL19350858 | 0.87 | MAPK14 (0.56) | MAPK14FLT3MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |