Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PI4KA | P42356 | 2/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350707 | 1.00 | MKNK1 (0.45) | MKNK1MKNK2FGFR1SRCMAPT | |
| SCHEMBL1208951 | 0.74 | HTT (0.72) | FGFR1HTTALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7989616 | 0.72 | HTT (0.70) | FGFR1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL5138709 | 0.72 | MKNK1 (0.56) | MKNK1MKNK2FGFR1SRCMAPT | |
| SCHEMBL19350758 | 0.71 | MKNK1 (0.46) | MKNK1MKNK2FGFR1MAPTHTT | |
| SCHEMBL31254392 | 0.71 | MAPT (0.45) | MKNK1MKNK2FGFR1SRCMAPT | |
| SCHEMBL900261 | 0.70 | GRM2 (0.46) | FGFR1SRCHTTCYP17A1 | |
| SCHEMBL19848258 | 0.69 | DDB1 (0.41) | ALDH1A1DHODHCYP17A1 | |
| SCHEMBL29435809 | 0.69 | DDB1 (0.41) | ALDH1A1DHODHCYP17A1 | |
| SCHEMBL5108457 | 0.69 | MKNK1 (0.41) | MKNK1MKNK2FGFR1SRCMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |