Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PIR | O00625 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uplarafenib SCHEMBL14716189 | 1.00 | BRAF (0.51) | BRAFPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL14716024 | 0.93 | BRAF (0.48) | BRAFPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL14715927 | 0.92 | BRAF (0.59) | BRAFCYP2C19CYP2C9CYP3A4BMPR1B | |
| SCHEMBL14716326 | 0.90 | BRAF (0.48) | BRAFPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL16506281 | 0.89 | BRAF (0.52) | BRAFPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL14715961 | 0.88 | BRAF (0.42) | BRAFCYP2C19CYP2C9CYP3A4 | |
| SCHEMBL17046454 | 0.88 | BRAF (0.47) | BRAFPIK3CACYP2C19CYP2C9CYP3A4 | |
| SCHEMBL14716305 | 0.88 | BRAF (0.46) | BRAFPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL14716140 | 0.87 | BRAF (0.52) | BRAFPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL14716129 | 0.87 | PIK3CB (0.44) | BRAFPIK3CAPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116887833-A | Certain chemical entities, compositions and methods | 润新生物公司 | 2023-10-13 | — | — | CN | claimed |
| EP-4255434-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Neupharma, Inc. (US) | 2023-10-11 | — | — | EP | claimed |
| WO-2022119905-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC (US) | 2022-06-09 | — | — | WO | claimed |
| CN-116887833-A | Certain chemical entities, compositions and methods | 润新生物公司 | 2023-10-13 | — | — | CN | disclosed |
| EP-4255434-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Neupharma, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022119905-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC (US) | 2022-06-09 | — | — | WO | disclosed |