Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MST1R | Q04912 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721655 | 0.88 | EGLN1 (0.41) | EGLN1CLK1HDAC8MAPK1RET | |
| SCHEMBL723198 | 0.83 | EGLN1 (0.44) | EGLN1CLK1HDAC8MAPK1MET | |
| SCHEMBL3804479 | 0.75 | GSK3B (0.41) | MAPK1RETMETGSK3BDYRK1A | |
| SCHEMBL285300 | 0.73 | ALK (0.55) | — | |
| SCHEMBL719766 | 0.71 | KDR (0.49) | EGLN1HDAC8MAPK1GSK3B | |
| SCHEMBL721257 | 0.69 | ALK (0.53) | — | |
| SCHEMBL719432 | 0.67 | ALK (0.58) | — | |
| SCHEMBL720700 | 0.66 | ALK (0.52) | — | |
| SCHEMBL10104635 | 0.65 | ALK (0.50) | — | |
| SCHEMBL10325548 | 0.65 | NTRK1 (0.40) | EGLN1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427461-B1 | 3-([1,2,3]TRIAZOL-4-YL)-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| EP-2427461-A1 | 3-(Ý1,2,3¨TRIAZOLE-4-YL)-PYRROLOÝ2,3-B¨PYRIDINE DERIVATES | Merck Patent GmbH (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127754-A1 | 3-([1,2,3]TRIAZOLE-4-YL)-PYRROLO[2,3-B]PYRIDINE DERIVATES | MERCK PATENT GMBH (DE) | 2010-11-11 | — | — | WO | disclosed |