Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 12/20 | 0.58 |
| ▸ | LCK | P06239 | 3/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.54 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.54 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29624345 | 0.91 | KDR (0.62) | KDREPHA2EPHB4EGFRLCK | |
| SCHEMBL29624383 | 0.88 | KDR (0.77) | KDREPHA2EPHB4EGFRLCK | |
| SCHEMBL28726470 | 0.88 | KDR (0.77) | KDREPHA2EPHB4EGFRLCK | |
| SCHEMBL29624348 | 0.80 | AURKB (0.71) | KDREGFRLCKRIPK2GAK | |
| SCHEMBL28726468 | 0.80 | AURKB (0.71) | KDREGFRLCKRIPK2GAK | |
| SCHEMBL28726464 | 0.80 | KDR (0.76) | KDREGFRLCKRIPK2GAK | |
| SCHEMBL28726465 | 0.80 | EGFR (0.66) | KDREGFRLCKRIPK2GAK | |
| SCHEMBL29624346 | 0.80 | EGFR (0.66) | KDREGFRLCKRIPK2GAK | |
| SCHEMBL28726466 | 0.80 | EGFR (0.69) | KDREGFRLCKRIPK2GAK | |
| SCHEMBL29624351 | 0.80 | EGFR (0.69) | KDREGFRLCKRIPK2GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109336828-B | Quinazoline derivative and preparation method and application thereof | 雅安职业技术学院 | 2022-04-26 | — | — | CN | disclosed |