Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 11/20 | 1.00 |
| ▸ | AXL | P30530 | 2/20 | 1.00 |
| ▸ | TYRO3 | Q06418 | 11/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377734 | 1.00 | MERTK (1.00) | MERTKAXLTYRO3 | |
| SCHEMBL19429706 | 0.88 | MERTK (0.79) | MERTKAXLTYRO3 | |
| SCHEMBL19398133 | 0.86 | TYRO3 (1.00) | MERTKAXLTYRO3 | |
| SCHEMBL19377963 | 0.84 | MERTK (0.80) | MERTKAXLTYRO3 | |
| SCHEMBL19398148 | 0.84 | MERTK (1.00) | MERTKAXLTYRO3 | |
| SCHEMBL31051670 | 0.84 | MERTK (0.80) | MERTKAXLTYRO3 | |
| SCHEMBL19398135 | 0.83 | MERTK (1.00) | MERTKAXLTYRO3 | |
| SCHEMBL19398149 | 0.80 | MERTK (1.00) | MERTKAXLTYRO3 | |
| SCHEMBL19377739 | 0.80 | TYRO3 (0.72) | MERTKAXLTYRO3 | |
| SCHEMBL19398127 | 0.79 | TYRO3 (1.00) | MERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | claimed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | claimed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |