SCHEMBL29626110

SCHEMBL29626110

Cc1c(-c2ccc(-c3cc(C4CCN(C(=O)C(C)C)CC4)n4ncnc(N)c34)cc2)c(C(N)=O)c(=O)n(-c2cncc(F)c2)c1C

nearest known ligand 0.68

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TYRO3 Q06418 10/20 0.68
▸ MERTK Q12866 11/20 0.61
▸ AXL P30530 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30874314 0.94 TYRO3 (0.67) TYRO3MERTKAXL
SCHEMBL29626193 0.91 TYRO3 (0.73) TYRO3MERTKAXL
SCHEMBL29626238 0.90 MERTK (0.66) TYRO3MERTKAXL
SCHEMBL29626179 0.90 TYRO3 (0.73) TYRO3MERTKAXL
SCHEMBL19377712 0.85 MERTK (0.72) TYRO3MERTKAXL
SCHEMBL29626214 0.84 MERTK (0.65) TYRO3MERTKAXL
SCHEMBL29626102 0.84 MERTK (0.65) TYRO3MERTKAXL
SCHEMBL26613641 0.83 MERTK (0.72) TYRO3MERTKAXL
SCHEMBL19377854 0.83 TYRO3 (0.85) TYRO3MERTKAXL
SCHEMBL29626154 0.82 MERTK (0.73) TYRO3MERTKAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114456175-B Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2024-09-03 — — CN disclosed
CN-114456176-B Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2024-08-30 — — CN disclosed
CN-114456175-A Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2022-05-10 — — CN disclosed
CN-114456176-A Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2022-05-10 — — CN disclosed
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