Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.89 |
| ▸ | IGF1R | P08069 | 8/20 | 0.77 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454660 | 0.94 | MAP2K1 (1.00) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL2971320 | 0.92 | IGF1R (0.88) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL2970786 | 0.92 | IGF1R (0.76) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL4443456 | 0.87 | IGF1R (1.00) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL2966953 | 0.85 | IGF1R (0.75) | MAP2K1IGF1REGFR | |
| SCHEMBL2961308 | 0.84 | IGF1R (0.89) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL2972917 | 0.84 | IGF1R (0.89) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL6183526 | 0.84 | IGF1R (0.89) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL4123817 | 0.84 | IGF1R (0.71) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL7001176 | 0.84 | MAP2K1 (0.77) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767671-B2 | 3-Quinolinecarbonitrile protein kinase inhibitors | WYETH (US) | 2010-08-03 | — | — | US | disclosed |
| US-20090062281-A1 | 3-QUINOLINECARBONITRILE PROTEIN KINASE INHIBITORS | WYETH (US) | 2009-03-05 | — | — | US | disclosed |
| US-7449460-B2 | 3-Quinolinecarbonitrile protein kinase inhibitors | WYETH (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2005082891-A1 | -QUINOLINECARBONITRILE PROTEIN KINASE INHIBITORS | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
| US-20050187247-A1 | 3-Quinolinecarbonitrile protein kinase inhibitors | WYETH (US) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062281-A1 | 3-QUINOLINECARBONITRILE PROTEIN KINASE INHIBITORS | RAF1, KRAS, NRAS | MAP2K1 89/4885IGF1R 862/4885MAPK3 11/4885 |
| US-20050187247-A1 | 3-Quinolinecarbonitrile protein kinase inhibitors | RAF1, KRAS, NRAS | MAP2K1 89/4885IGF1R 862/4885MAPK3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.