SCHEMBL29629470

SCHEMBL29629470

Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cnc2ccccn12

nearest known ligand 0.75

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 15/20 0.75
KIT P10721 1/20 0.65
DDR1 Q08345 1/20 0.65
DDR2 Q16832 1/20 0.65
LCK P06239 4/20 0.64
KDR P35968 4/20 0.64
TEK Q02763 4/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL589532 0.87 ABL1 (0.67) ABL1DDR1DDR2
SCHEMBL16644465 0.85 ABL1 (1.00) ABL1KITDDR1DDR2LCK
SCHEMBL9611012 0.85 ABL1 (0.70) ABL1
SCHEMBL15061698 0.85 ABL1 (0.74) ABL1KITDDR1DDR2LCK
SCHEMBL24123127 0.84 ABL1 (0.78) ABL1DDR1DDR2
SCHEMBL588964 0.84 ABL1 (0.81) ABL1
SCHEMBL588662 0.84 ABL1 (1.00) ABL1DDR1DDR2
SCHEMBL29493473 0.84 ABL1 (0.81) ABL1
SCHEMBL9611023 0.84 ABL1 (0.89) ABL1KITDDR1DDR2
SCHEMBL10207605 0.83 ABL1 (0.76) ABL1DDR1DDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3473624-B1 NOVEL IMIDAZOPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR) 2022-05-11 EP disclosed