SCHEMBL29629487

SCHEMBL29629487

Clc1ccc(Oc2ccc(Cl)c(Cl)c2I)c(I)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.33
NR1I2 O75469 1/20 0.33
LMNA P02545 1/20 0.33
TTR P02766 1/20 0.33
PGR P06401 1/20 0.33
HSP90AA1 P07900 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
MAPT P10636 1/20 0.33
HSPA5 P11021 1/20 0.33
HPGD P15428 1/20 0.33
CBR1 P16152 1/20 0.33
TBXA2R P21731 1/20 0.33
SLC6A2 P23975 1/20 0.33
AGTR1 P30556 1/20 0.33
SLC6A3 Q01959 1/20 0.33
CYP3A4 P08684 1/20 0.33
MAPK1 P28482 1/20 0.33
RHEB Q15382 1/20 0.32
NOTUM Q6P988 1/20 0.31
CYP2A6 P11509 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22118215 1.00 AKR1B1 (0.33) AKR1B1NR1I2LMNATTRPGR
SCHEMBL29663805 0.81 HTR2A (0.42) LMNAHSP90AA1MAPTHPGDMAPK1
SCHEMBL23214517 0.81 HTR2A (0.42) LMNAHSP90AA1MAPTHPGDMAPK1
SCHEMBL22138543 0.78 HTR2A (0.37) LMNAMAPTHPGDCYP3A4MAPK1
SCHEMBL11283671 0.76 CYP3A4 (0.43) AKR1B1NR1I2LMNATTRPGR
SCHEMBL10873226 0.75 CYP3A4 (0.41) LMNACYP3A4MAPK1NOTUMCYP2A6
SCHEMBL11057310 0.73 KDM4E (0.46) HPGDCYP3A4MAPK1
SCHEMBL29745618 0.72 HTR2C (0.51) HPGDMAPK1HTR2AHTR2CHTR2B
SCHEMBL23215810 0.72 HTR2C (0.51) HPGDMAPK1HTR2AHTR2CHTR2B
SCHEMBL31533664 0.71 MAPK14 (0.50) MAPTHPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12297311-B2 Biaryl hydroxythiophene group IV transition metal polymerization with chain transfer capability DOW GLOBAL TECHNOLOGIES LLC (US) 2025-05-13 US disclosed
US-12221508-B2 Biaryl phenoxy group IV transition metal catalysts for olefin polymerization DOW GLOBAL TECHNOLOGIES LLC (US) 2025-02-11 US disclosed
US-20220169756-A1 BIARYL HYDROXYTHIOPHENE GROUP IV TRANSITION METAL POLYMERIZATION WITH CHAIN TRANSFER CAPABILITY DOW GLOBAL TECHNOLOGIES LLC (US) 2022-06-02 US disclosed