Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24494407 | 1.00 | MCHR1 (0.47) | MCHR1ADRA2ACRHR1GAAMAPT | |
| SCHEMBL29522469 | 0.92 | GRM5 (0.48) | — | |
| SCHEMBL31166042 | 0.92 | GAA (0.47) | MCHR1ADRA2ACRHR1GAAMAPT | |
| SCHEMBL29632297 | 0.92 | GAA (0.47) | MCHR1ADRA2ACRHR1GAAMAPT | |
| SCHEMBL24360067 | 0.92 | GAA (0.47) | MCHR1ADRA2ACRHR1GAAMAPT | |
| SCHEMBL24360099 | 0.92 | GAA (0.47) | MCHR1ADRA2ACRHR1GAAMAPT | |
| SCHEMBL25111386 | 0.92 | GRM5 (0.48) | — | |
| SCHEMBL24494276 | 0.92 | SMYD3 (0.51) | MCHR1ADRA2ACRHR1GAAMAPT | |
| SCHEMBL29632563 | 0.92 | SMYD3 (0.51) | MCHR1ADRA2ACRHR1GAAMAPT | |
| SCHEMBL24360046 | 0.91 | MCHR1 (0.48) | MCHR1ADRA2ACRHR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710434-A | Modulators of MAS-related G protein receptor X2 and related products and uses thereof | 伊赛恩特制药公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-4232042-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087083-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |