Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.62 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110550 | 1.00 | NTRK1 (0.62) | NTRK1NTRK3 | |
| SCHEMBL17111096 | 0.88 | NTRK1 (0.59) | NTRK1NTRK3 | |
| SCHEMBL17130017 | 0.88 | NTRK1 (0.63) | NTRK1 | |
| SCHEMBL17110681 | 0.85 | NTRK1 (0.59) | NTRK1NTRK3 | |
| SCHEMBL17110737 | 0.83 | NTRK1 (0.55) | NTRK1NTRK3 | |
| SCHEMBL17110581 | 0.80 | NTRK1 (0.59) | NTRK1NTRK3 | |
| SCHEMBL17110584 | 0.79 | NTRK1 (0.63) | NTRK1NTRK3 | |
| SCHEMBL17111464 | 0.78 | NTRK1 (0.61) | NTRK1 | |
| SCHEMBL17111157 | 0.78 | NTRK1 (1.00) | NTRK1NTRK3 | |
| SCHEMBL17110589 | 0.77 | NTRK1 (0.60) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122344-B1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME (US) | 2022-04-27 | — | — | EP | disclosed |