Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17129865 | 0.92 | NTRK1 (0.52) | NTRK1NPC1LMNATP53RAB9A | |
| SCHEMBL17112106 | 0.84 | NTRK1 (0.56) | NTRK1 | |
| SCHEMBL29633327 | 0.83 | KMT2A (0.41) | NTRK1NPC1LMNATP53RAB9A | |
| SCHEMBL17129864 | 0.82 | NTRK1 (0.44) | NTRK1NPC1LMNATP53RAB9A | |
| SCHEMBL17129866 | 0.80 | NTRK1 (0.44) | NTRK1 | |
| SCHEMBL18748527 | 0.79 | NTRK1 (0.44) | NTRK1 | |
| SCHEMBL17129880 | 0.78 | NTRK1 (0.42) | NTRK1NPC1LMNATP53RAB9A | |
| SCHEMBL24376161 | 0.77 | NTRK1 (0.42) | NTRK1NPC1LMNATP53RAB9A | |
| SCHEMBL17129957 | 0.77 | NTRK1 (0.54) | NTRK1NPC1LMNATP53RAB9A | |
| SCHEMBL17129960 | 0.77 | NPC1 (0.41) | NTRK1NPC1LMNATP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122344-B1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME (US) | 2022-04-27 | — | — | EP | disclosed |