SCHEMBL29635165

SCHEMBL29635165

N#CC1CCN(c2nc(Nc3ccc(CN4CCC(C(=O)O)CC4)cc3)c3c(=O)[nH]ncc3n2)CC1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 17/20 0.83
JAK2 O60674 11/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14717018 1.00 SYK (0.83) SYKJAK2
SCHEMBL14716657 0.92 SYK (0.75) SYKJAK2
SCHEMBL29635149 0.92 SYK (0.75) SYKJAK2
SCHEMBL29635209 0.92 SYK (0.87) SYKJAK2
SCHEMBL14717229 0.92 SYK (0.87) SYKJAK2
SCHEMBL14716836 0.91 SYK (1.00) SYKJAK2
SCHEMBL29635110 0.91 SYK (1.00) SYKJAK2
SCHEMBL29635138 0.90 SYK (0.82) SYKJAK2
SCHEMBL14716793 0.90 SYK (0.82) SYKJAK2
SCHEMBL14728752 0.90 SYK (0.79) SYKJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108707151-B Pyrimido-pyridazinone compounds and uses thereof 阿萨纳生物科技有限责任公司 2022-06-03 CN claimed
EP-3392252-B1 PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF LIBERTAS BIO INC (US) 2023-10-04 EP disclosed
CN-108707151-B Pyrimido-pyridazinone compounds and uses thereof 阿萨纳生物科技有限责任公司 2022-06-03 CN disclosed