Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.68 |
| ▸ | JAK2 | O60674 | 11/20 | 0.65 |
| ▸ | JAK1 | P23458 | 1/20 | 0.65 |
| ▸ | TYK2 | P29597 | 1/20 | 0.65 |
| ▸ | JAK3 | P52333 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14716998 | 1.00 | SYK (0.68) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL29635070 | 0.91 | SYK (0.80) | SYKJAK2 | |
| SCHEMBL14716985 | 0.91 | SYK (0.80) | SYKJAK2 | |
| SCHEMBL30604953 | 0.91 | SYK (0.82) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14716628 | 0.91 | SYK (0.82) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL30604874 | 0.91 | JAK2 (0.80) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717260 | 0.91 | JAK2 (0.80) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717824 | 0.91 | SYK (0.72) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL30604873 | 0.91 | SYK (0.72) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717287 | 0.90 | SYK (0.83) | SYKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | claimed |
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |