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SCHEMBL29635409

SCHEMBL29635409

CN1CCN(C(=O)Cn2c(=O)[nH]c3ncc(-c4cccc(C(F)(F)F)c4)cc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ GRIN1 Q05586 20/20 1.00
▸ GRIN2B Q13224 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20134037 1.00 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134492 0.92 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635517 0.92 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134386 0.92 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635470 0.92 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635381 0.91 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134042 0.91 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134191 0.90 GRIN1 (0.86) GRIN1GRIN2B
SCHEMBL20134030 0.89 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635382 0.89 GRIN1 (1.00) GRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114989164-A Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-09-02 — — CN claimed
CN-110062761-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-05-13 — — CN claimed
CN-114989164-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2024-08-13 — — CN disclosed