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SCHEMBL29635453

SCHEMBL29635453

Cn1c(=O)n(CC(=O)N2CCC2)c2cc(-c3ccc(F)c(F)c3)cnc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ GRIN1 Q05586 20/20 1.00
▸ GRIN2B Q13224 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20130154 1.00 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635515 0.92 GRIN2B (0.85) GRIN1GRIN2B
SCHEMBL20130144 0.92 GRIN2B (0.85) GRIN1GRIN2B
SCHEMBL20130206 0.90 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635425 0.90 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20130141 0.90 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635412 0.90 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20130148 0.88 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20130135 0.88 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29635501 0.88 GRIN1 (1.00) GRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114989164-A Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-09-02 — — CN claimed
CN-110062761-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-05-13 — — CN claimed
CN-114989164-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2024-08-13 — — CN disclosed