SCHEMBL29635484

SCHEMBL29635484

COc1ccc(-c2cnc3[nH]c(=O)n(CC(=O)NC4CC4)c3c2)c(Cl)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 20/20 1.00
GRIN2B Q13224 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20134018 1.00 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134378 0.91 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134417 0.87 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL30176705 0.87 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134530 0.85 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134372 0.84 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL30532164 0.84 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134402 0.80 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL20134185 0.80 GRIN2B (1.00) GRIN1GRIN2B
SCHEMBL20134545 0.79 GRIN1 (1.00) GRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114989164-A Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-09-02 CN claimed
CN-110062761-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-05-13 CN claimed
CN-114989164-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2024-08-13 CN disclosed
CN-114989164-A Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-09-02 CN disclosed
CN-110062761-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-05-13 CN disclosed