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SCHEMBL29635522

SCHEMBL29635522

CN(C)C(=O)Cn1c(=O)n(C)c2ncc(-c3cccc(C(F)(F)F)c3F)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ GRIN2B Q13224 20/20 1.00
▸ GRIN1 Q05586 16/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20130156 1.00 GRIN2B (1.00) GRIN2BGRIN1
SCHEMBL20130157 0.88 GRIN1 (1.00) GRIN2BGRIN1
SCHEMBL29635460 0.88 GRIN1 (1.00) GRIN2BGRIN1
SCHEMBL20130159 0.87 GRIN2B (1.00) GRIN2BGRIN1
SCHEMBL29635448 0.87 GRIN2B (1.00) GRIN2BGRIN1
SCHEMBL20130163 0.83 GRIN1 (1.00) GRIN2BGRIN1
SCHEMBL29635451 0.83 GRIN1 (1.00) GRIN2BGRIN1
SCHEMBL29635433 0.83 GRIN2B (1.00) GRIN2BGRIN1
SCHEMBL20130146 0.83 GRIN2B (1.00) GRIN2BGRIN1
SCHEMBL29635445 0.82 GRIN1 (1.00) GRIN2BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114989164-A Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-09-02 — — CN claimed
CN-110062761-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2022-05-13 — — CN claimed
CN-114989164-B Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof 詹森药业有限公司 2024-08-13 — — CN disclosed