Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 12/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.50 |
| ▸ | PARG | Q86W56 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129922 | 1.00 | GRIN1 (0.65) | GRIN1GRIN2BHSD17B10TRPA1PARG | |
| SCHEMBL28736749 | 0.81 | GRIN2B (0.53) | GRIN1GRIN2BTRPA1GABRA5GABRA1 | |
| SCHEMBL31008704 | 0.81 | GRIN2B (0.53) | GRIN1GRIN2BTRPA1GABRA5GABRA1 | |
| SCHEMBL20129925 | 0.80 | GRIN1 (0.66) | GRIN1GRIN2BHSD17B10TRPA1PARG | |
| SCHEMBL25253002 | 0.79 | GRIN1 (0.57) | GRIN1GRIN2BTRPA1PARGGABRA5 | |
| SCHEMBL20130187 | 0.79 | GRIN1 (1.00) | GRIN1GRIN2B | |
| SCHEMBL20129962 | 0.78 | GRIN1 (1.00) | GRIN1GRIN2B | |
| SCHEMBL20129960 | 0.78 | GRIN1 (1.00) | GRIN1GRIN2B | |
| SCHEMBL31008724 | 0.78 | GRIN1 (0.62) | GRIN1GRIN2BHSD17B10PARG | |
| SCHEMBL20129924 | 0.78 | GRIN1 (0.62) | GRIN1GRIN2BHSD17B10PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989164-B | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2024-08-13 | — | — | CN | disclosed |
| CN-114989164-A | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-110062761-B | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-05-13 | — | — | CN | disclosed |