Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 17/20 | 0.41 |
| ▸ | CA2 | P00918 | 16/20 | 0.41 |
| ▸ | CA12 | O43570 | 12/20 | 0.41 |
| ▸ | CA9 | Q16790 | 12/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gw305178X SCHEMBL5894133 | 1.00 | EIF2AK2 (0.46) | EIF2AK2CA1CA2CA12CA9 | |
| Gw305178X SCHEMBL5894138 | 1.00 | EIF2AK2 (0.46) | EIF2AK2CA1CA2CA12CA9 | |
| SCHEMBL12856312 | 0.83 | EIF2AK2 (0.46) | EIF2AK2CA1CA2CA12CA9 | |
| SCHEMBL5893985 | 0.81 | CYP1A2 (0.35) | CYP1A2 | |
| SCHEMBL5893988 | 0.81 | CYP1A2 (0.35) | CYP1A2 | |
| SCHEMBL5893496 | 0.79 | EIF2AK2 (0.47) | EIF2AK2CA1CA2CA12CA9 | |
| SCHEMBL5893487 | 0.79 | EIF2AK2 (0.47) | EIF2AK2CA1CA2CA12CA9 | |
| SCHEMBL6619758 | 0.79 | EIF2AK2 (0.47) | EIF2AK2CA1CA2CA12CA9 | |
| SCHEMBL12856344 | 0.79 | EIF2AK2 (0.47) | EIF2AK2CA1CA2CA12CA9 | |
| SCHEMBL5773570 | 0.78 | CYP1A2 (0.48) | MAPTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220281930-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL PAIN AND ITCH | DUKE UNIVERSITY (US) | 2022-09-08 | — | — | US | disclosed |
| EP-4017873-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL PAIN AND ITCH | Duke University (US) | 2022-06-29 | — | — | EP | disclosed |