Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.91 |
| ▸ | ARG2 | P78540 | 4/20 | 0.59 |
| ▸ | ARG1 | P05089 | 3/20 | 0.55 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 4/20 | 0.52 |
| ▸ | NOS1 | P29475 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GGT1 | P19440 | 2/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL11904964 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL8046798 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL3823204 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL27860697 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL27860695 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL449696 | 1.00 | GSR (0.91) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL12470729 | 0.98 | GSR (0.87) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL318676 | 0.98 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL1220993 | 0.98 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL10582149 | 0.98 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112679371-B | Preparation method of L-lysine hydrochloride beta crystal form | 北京民康百草医药科技有限公司 | 2022-11-18 | — | — | CN | claimed |
| CN-112679371-A | Preparation method of L-lysine hydrochloride beta crystal form | 北京民康百草医药科技有限公司 | 2021-04-20 | — | — | CN | claimed |
| US-4256917-A | Anhydrous L-lysine monohydrochloride in α-cyrstalline form and preparation thereof | AJINOMOTO COMPANY, LIMITED (JP) | 1981-03-17 | — | — | US | claimed |
| JP-57045145-A | — | — | None | — | — | JP | disclosed |
| CN-116410102-A | L-lysine crystal form and preparation method thereof | 武汉瑞晟药业有限公司 | 2023-07-11 | — | — | CN | disclosed |
| CN-112679371-B | Preparation method of L-lysine hydrochloride beta crystal form | 北京民康百草医药科技有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-112679371-B | Preparation method of L-lysine hydrochloride beta crystal form | 北京民康百草医药科技有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-112679371-A | Preparation method of L-lysine hydrochloride beta crystal form | 北京民康百草医药科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-112679371-A | Preparation method of L-lysine hydrochloride beta crystal form | 北京民康百草医药科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| US-10610470-B2 | Oral care composition zinc-lysine complex | COLGATE-PALMOLIVE COMPANY (US) | 2020-04-07 | — | — | US | disclosed |
| US-20190117536-A1 | Oral Care Composition Comprising Zinc-Lysine Complex | COLGATE-PALMOLIVE COMPANY (US) | 2019-04-25 | — | — | US | disclosed |
| WO-1998054351-A1 | A COMBINED PROCESS FOR THE PRODUCTION OF LYSINE AND ITS SALTS AND OF A FURTHER WEAK ACID AND A SALT THEREOF | AMYLUM BELGIUM N.V. (BE) | 1998-12-03 | — | — | WO | disclosed |
| EP-0719715-B1 | A package for preventing caking of powders and granules | AJINOMOTO KK (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5657866-A | DOUBLE PACKAGING: INNER CONTAINER HAVING HIGH WATER VAPOR PERMEABILITY AND OUTER CONTAINER HAVING NONE WITH DESICCANTS PLACED BETWEEN | AJINOMOTO CO., INC. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5250423-A | Culturing mutant strain which is resistant to S-/2-aminoethyl/ -L-cysteine | AJINOMOTO CO., INC. (JP) | 1993-10-05 | — | — | US | disclosed |
| US-5164307-A | Biosynthesis | AJINOMOTO CO., INC. (JP) | 1992-11-17 | — | — | US | disclosed |
| US-5164306-A | Production of L-amino acids | AJINOMOTO CO., INC. (JP) | 1992-11-17 | — | — | US | disclosed |
| JP-S5745145-A | PREPARATION OF PACKAGED LYSINE HYCROCHLORIDE | AJINOMOTO CO INC | 1982-03-13 | — | — | JP | disclosed |
| US-4276380-A | VALINE BY CULTURING ACINETOBACTER | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1981-06-30 | — | — | US | disclosed |
| US-4256917-A | Anhydrous L-lysine monohydrochloride in α-cyrstalline form and preparation thereof | AJINOMOTO COMPANY, LIMITED (JP) | 1981-03-17 | — | — | US | disclosed |