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SCHEMBL29638066

SCHEMBL29638066

C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 1/20 0.61
▸ C5AR1 P21730 1/20 0.60
▸ CALCR P30988 5/20 0.58
▸ RAMP3 O60896 1/20 0.58
▸ F2 P00734 4/20 0.58
▸ NPY2R P49146 3/20 0.57
▸ NPY4R P50391 3/20 0.57
▸ NPY5R Q15761 3/20 0.57
▸ NPY1R P25929 2/20 0.57
▸ NMUR2 Q9GZQ4 1/20 0.57
▸ NMUR1 Q9HB89 1/20 0.57
▸ CTSL P07711 1/20 0.56
▸ CTSH P09668 1/20 0.56
▸ CTSS P25774 1/20 0.56
▸ CTSK P43235 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29638059 1.00 MC4R (0.61) MC4RC5AR1CALCRRAMP3F2
SCHEMBL30034800 0.92 CALCR (0.61) MC4RC5AR1CALCRRAMP3NPY2R
SCHEMBL30233814 0.91 C5AR1 (0.63) MC4RC5AR1CALCRRAMP3F2
SCHEMBL30208250 0.91 EPHA2 (0.56) MC4RC5AR1F2NPY2RNPY4R
SCHEMBL30032896 0.91 C5AR1 (0.61) MC4RC5AR1CALCRRAMP3NPY2R
SCHEMBL29593655 0.90 C5AR1 (0.69) MC4RC5AR1F2NPY2RNPY4R
SCHEMBL29593115 0.90 C5AR1 (0.69) MC4RC5AR1F2NPY2RNPY4R
SCHEMBL29593954 0.90 C5AR1 (0.69) MC4RC5AR1F2NPY2RNPY4R
SCHEMBL29880330 0.90 C5AR1 (0.64) MC4RC5AR1NPY2RNPY4RNPY5R
SCHEMBL30753758 0.89 C5AR1 (0.63) MC4RC5AR1CALCRRAMP3F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4591934-A2 VARIANTS OF C-TYPE NATRIURETIC PEPTIDE BioMarin Pharmaceutical Inc. (US) 2025-07-30 — — EP disclosed
EP-4523749-A2 VARIANTS OF C-TYPE NATRIURETIC PEPTIDE BioMarin Pharmaceutical Inc. (US) 2025-03-19 — — EP disclosed
EP-4029512-A1 VARIANTS OF C-TYPE NATRIURETIC PEPTIDE BioMarin Pharmaceutical Inc. (US) 2022-07-20 — — EP disclosed
EP-4019038-A2 USE OF C-TYPE NATRIURETIC PEPTIDE VARIANTS TO TREAT OSTEOARTHRITIS BioMarin Pharmaceutical Inc. (US) 2022-06-29 — — EP disclosed
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