Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14674173 | 1.00 | FLT3 (0.76) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL14674172 | 1.00 | FLT3 (0.76) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL14674292 | 0.89 | NPC1 (0.74) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL14674291 | 0.89 | NPC1 (0.74) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL29638267 | 0.88 | FLT3 (0.71) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL14675110 | 0.86 | MEN1 (1.00) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL3283724 | 0.86 | FLT3 (1.00) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL3283720 | 0.86 | FLT3 (1.00) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL29638274 | 0.86 | MEN1 (0.72) | FLT3MEN1KMT2ANPC1RPS6KA3 | |
| SCHEMBL14675111 | 0.86 | MEN1 (1.00) | FLT3MEN1KMT2ANPC1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116452-B | Indolone derivatives with alpha-glucosidase inhibitory activity as well as preparation method and application thereof | 五邑大学 | 2022-05-03 | — | — | CN | disclosed |