Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14674268 | 1.00 | FLT3 (0.64) | FLT3KDRLRRK2MEN1KMT2A | |
| SCHEMBL14674269 | 1.00 | FLT3 (0.64) | FLT3KDRLRRK2MEN1KMT2A | |
| SCHEMBL14674419 | 0.88 | KDR (0.72) | FLT3KDRLRRK2MEN1KMT2A | |
| SCHEMBL29638292 | 0.88 | KDR (0.72) | FLT3KDRLRRK2MEN1KMT2A | |
| SCHEMBL14674418 | 0.88 | KDR (0.72) | FLT3KDRLRRK2MEN1KMT2A | |
| SCHEMBL14674289 | 0.87 | LRRK2 (0.76) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14674288 | 0.87 | LRRK2 (0.76) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7139500 | 0.86 | MAPT (0.63) | FLT3KDRLRRK2MEN1KMT2A | |
| SCHEMBL29638269 | 0.86 | LRRK2 (0.67) | FLT3KDRLRRK2MEN1KMT2A | |
| SCHEMBL5469417 | 0.85 | KDR (0.73) | FLT3KDRMEN1KMT2APSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116452-B | Indolone derivatives with alpha-glucosidase inhibitory activity as well as preparation method and application thereof | 五邑大学 | 2022-05-03 | — | — | CN | disclosed |