Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PRKDC | P78527 | 3/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557287 | 1.00 | BTK (0.42) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL24557282 | 0.88 | POLB (0.42) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL29638556 | 0.88 | POLB (0.42) | BTKJAK2JAK1TYK2JAK3 | |
| SCHEMBL29638478 | 0.88 | MEN1 (0.42) | BTKPLK1MEN1KMT2AMAPT | |
| SCHEMBL24557279 | 0.88 | MEN1 (0.42) | BTKPLK1MEN1KMT2AMAPT | |
| SCHEMBL29638400 | 0.86 | LYN (0.42) | BTKTYK2PLK1MEN1KMT2A | |
| SCHEMBL24557271 | 0.85 | SRC (0.46) | BTKJAK2JAK1TYK2PLK1 | |
| SCHEMBL29638496 | 0.85 | SRC (0.46) | BTKJAK2JAK1TYK2PLK1 | |
| SCHEMBL24557286 | 0.84 | LYN (0.48) | BTKPLK1MEN1KMT2AMAPT | |
| SCHEMBL24557289 | 0.84 | LYN (0.42) | BTKPLK1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |