Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.59 |
| ▸ | RAF1 | P04049 | 11/20 | 0.59 |
| ▸ | CSF1R | P07333 | 11/20 | 0.59 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.59 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.59 |
| ▸ | ARAF | P10398 | 1/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24399662 | 1.00 | BRAF (0.59) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL24399670 | 0.90 | BRAF (0.64) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL29638667 | 0.90 | BRAF (0.64) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL29638529 | 0.89 | BRAF (0.71) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL24399695 | 0.89 | BRAF (0.65) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL29638694 | 0.89 | BRAF (0.65) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL24399660 | 0.89 | BRAF (0.71) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL24399672 | 0.87 | BRAF (0.59) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL29638695 | 0.87 | BRAF (0.59) | BRAFRAF1CSF1RDDR2DDR1 | |
| SCHEMBL24399592 | 0.84 | BRAF (0.71) | BRAFRAF1CSF1RDDR2DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096718-A | Aryl amide compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |