Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.49 |
| ▸ | RAF1 | P04049 | 10/20 | 0.49 |
| ▸ | CSF1R | P07333 | 5/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ARAF | P10398 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24399601 | 1.00 | BRAF (0.49) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL24399635 | 0.88 | RAF1 (0.62) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL29638605 | 0.88 | RAF1 (0.62) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL29638501 | 0.84 | BRAF (0.52) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL25375784 | 0.84 | BRAF (0.52) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL24399605 | 0.84 | RAF1 (0.63) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL29638514 | 0.84 | RAF1 (0.63) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL25373039 | 0.83 | RAF1 (0.49) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL29638609 | 0.83 | RAF1 (0.49) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL24399631 | 0.81 | RAF1 (0.64) | BRAFRAF1CSF1RDDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |