Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 9/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | MERTK | Q12866 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28516648 | 1.00 | LRRK2 (0.52) | LRRK2METMAP4K4IKBKETBK1 | |
| SCHEMBL21779385 | 0.79 | LRRK2 (0.60) | LRRK2METMAP4K4IKBKETBK1 | |
| SCHEMBL15174551 | 0.78 | PRMT5 (0.50) | LRRK2METMAP4K4AURKATTK | |
| SCHEMBL16679332 | 0.78 | LRRK2 (0.55) | LRRK2METMAP4K4IKBKETBK1 | |
| SCHEMBL21557014 | 0.78 | LRRK2 (0.55) | LRRK2METMAP4K4IKBKETBK1 | |
| SCHEMBL992070 | 0.77 | ERN1 (0.55) | LRRK2METMAP4K4IKBKETBK1 | |
| SCHEMBL19662785 | 0.76 | AURKA (0.54) | LRRK2AURKATTKAURKBINCENP | |
| SCHEMBL18611803 | 0.76 | IKBKE (0.62) | LRRK2METMAP4K4IKBKETBK1 | |
| SCHEMBL18586051 | 0.76 | IKBKE (0.62) | METMAP4K4IKBKETBK1AXL | |
| SCHEMBL28733506 | 0.76 | PIK3CD (0.40) | METMAP4K4AXLMAPK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450005-A | Compounds for the treatment of neurological disorders | 星座制药公司 | 2022-05-06 | — | — | CN | disclosed |